The incident unfolded at a home near the Honolulu tourist destination when authorities were responding to a domestic violence call, officials said.
Honolulu police responded to reports of a woman who was stabbed in Waikiki when the officers arriving on scene came under fire from the suspect. Police believe the suspect, who may have been using an AR-15-style rifle, is dead, but they have yet to confirm that due to the fire.
The two police officers were identified as Tiffany Enriquez, a seven-year veteran, and Kaulike Kalama, a nine-year veteran. Both were wearing bulletproof vests, but were hit above them, police said.
Hawaii Gov. David Ige confirmed the officers' deaths on Twitter.
"Our entire state mourns the loss of two Honolulu Police officers killed in the line of duty this morning," Ige wrote. "As we express our condolences to their families, friends and colleagues, let us also come together to help and support those who have been forever changed by this tragedy."
Police said in addition to the suspect, two other people are also unaccounted for from a house that burned to the ground.
The suspect has been identified as Jerry Hanel, who is in his 60s. Police said they will continue searching for the suspect until his remains have been recovered.
Seven homes were totally destroyed in the fire and others suffered smoke damage, officials said. Read more at ABC News